亚娱体育

讲座人:KinFai Au教授

讲座时间:7月20日16:00-17:00

讲座地点:长安校区会议中心121会议室

讲座人介绍:

Kin Fai Au(区健辉)教授2004年本科毕业于清华亚娱体育官方活动，2009年于牛津亚娱体育官方活动获得博士学位，2009年至2013年在斯坦福亚娱体育官方活动师从美国科学院院士WingH.Wong教授从事博士后研究，2013年在爱荷华亚娱体育官方活动建立实验室直到2018年转至俄亥俄州立亚娱体育官方活动。在俄亥俄州立亚娱体育官方活动期间，曾任职生物医学信息学系副系主任(研究)及博士课程主任。2023年加入密歇根亚娱体育官方活动担任终身正教授。主要从事测序数据(尤其是长读长数据)的统计方法和计算方法(如genome lanauge model)方法开发，近年来在ENature Biotechnology,Nature Methods, Nature Structural& Molecular Biology等期刊发表了多篇关于长读长测序，RNA修饰，基因异构体和转座子的高水平论文。区教授是The Long-read RNA-seq Genome Annotation Assessment Project (LRGASP) Consortium主要负责人之一，并且担任著名学术期刊Genome Biology和Genome Research的编委。

讲座内容:

Long-read sequencing has been widely adopted in transcriptomics research, particularly for identifying novel and complex transcriptomic events. As the cost and throughput of long-readsequencing have been improved, the applications to quantitative transcriptome analysis are emerging. Here I will present the development of the "K-value", which is designed to: (1) quantify the influence of gene isoform structural complexity on expression esstimation via data deconvolution; and (2) rigorously demonstrate the advantages of long reads over short reads in isoform quantification through mathematical modeling, simulations, experimental validation, and large-scale public datasets. I also will present thesoftware miniQuant that integrates short reads and long reads in a gene- and data-specific manner to achieve better gene isoformquantification over long reads alone and short reads alone. The proof-of-concept applications include the discoveries of gene isoform switching during stem cell differentiation and unique pattern of zygotic genome activation of transposable elements.

主办单位:生命科学技术学院

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